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. 2025 Feb 25;35(2):129–167. doi: 10.25259/ijn_389_23
Characteristics of an ideal agent for the treatment of anemia in CKD

Targeting the underlying cause of anemia: Ideally, the agent should work by targeting the underlying causes of anemia, such as decreased erythropoietin (EPO) production and iron deficiency rather than simply increasing erythropoiesis.

Efficacy: The agent should be effective at increasing hemoglobin levels and improving anemia-related symptoms in patients with CKD.

Safety: The agent should be safe and have a favorable benefit-risk profile with minimal risk of serious side effects such as cardiovascular events and cancers.

Convenience of use: The agent should be easy to administer with minimal monitoring requirements and few or no dietary restrictions.

Cost-effective: The agent should be cost-effective and affordable for patients and not require prolonged treatment.

Preservation of kidney function: The agent should not negatively impact on the kidney function, and if possible, should improve it.