Table 2.
The 80 SNPs associated with GERD from a GWAS involving UK Biobank participants that were available in the SAS GWAS and included in the GERD-SAS MR analyses
| SNP | Chr | Position | Effect allele | Other allele | EAF | βa | P |
|---|---|---|---|---|---|---|---|
| rs10010963 | 4 | 159,839,313 | T | C | 0.62 | − 0.03 | 4.9E−08 |
| rs1011407 | 2 | 60,665,768 | G | A | 0.12 | − 0.04 | 1.1E−08 |
| rs10133111 | 14 | 103,377,321 | A | G | 0.16 | 0.04 | 1.4E−10 |
| rs1021363 | 10 | 106,610,839 | G | A | 0.64 | − 0.03 | 5.1E−10 |
| rs10837002 | 11 | 38,565,727 | G | C | 0.35 | 0.03 | 4.0E−08 |
| rs11762636 | 7 | 2,061,111 | A | C | 0.18 | − 0.05 | 1.9E−16 |
| rs11953061 | 5 | 120,144,025 | T | C | 0.34 | 0.03 | 3.1E−08 |
| rs12204714 | 6 | 152,235,339 | T | C | 0.63 | − 0.03 | 7.9E−09 |
| rs12357321 | 10 | 21,790,476 | A | G | 0.31 | 0.03 | 1.3E−09 |
| rs12453010 | 17 | 50,316,131 | T | C | 0.40 | 0.03 | 1.7E−09 |
| rs12598916 | 16 | 60,658,751 | G | C | 0.28 | − 0.03 | 6.9E−10 |
| rs12967855 | 18 | 35,138,245 | G | A | 0.67 | − 0.04 | 1.1E−12 |
| rs12997558 | 2 | 41,704,580 | A | G | 0.36 | 0.03 | 3.0E−08 |
| rs13107325 | 4 | 103,188,709 | T | C | 0.07 | 0.07 | 2.2E−14 |
| rs1334297 | 13 | 58,335,375 | A | G | 0.73 | − 0.04 | 1.1E−12 |
| rs13409451 | 2 | 144,257,639 | G | A | 0.39 | − 0.03 | 1.9E−08 |
| rs1431196 | 18 | 50,832,102 | G | A | 0.43 | 0.03 | 2.7E−11 |
| rs1479405 | 12 | 15,387,519 | T | C | 0.32 | 0.03 | 9.9E−10 |
| rs1510719 | 4 | 140,938,116 | C | T | 0.38 | − 0.04 | 3.8E−15 |
| rs1592757 | 5 | 103,889,998 | C | G | 0.36 | 0.03 | 6.0E−10 |
| rs1596747 | 2 | 193,802,478 | G | A | 0.49 | 0.03 | 1.0E−10 |
| rs1716171 | 12 | 123,716,376 | T | C | 0.79 | 0.04 | 7.8E−11 |
| rs17379561 | 1 | 98,340,139 | T | A | 0.14 | 0.05 | 1.1E−14 |
| rs1883842 | 20 | 41,223,062 | G | T | 0.28 | 0.03 | 9.3E−09 |
| rs1937450 | 1 | 66,478,840 | G | T | 0.54 | 0.03 | 7.1E−11 |
| rs2016933 | 3 | 65,653,157 | G | C | 0.73 | − 0.03 | 1.0E−08 |
| rs2023878 | 19 | 18,834,124 | T | C | 0.19 | − 0.04 | 3.0E−09 |
| rs2043539 | 7 | 12,253,880 | A | G | 0.42 | 0.03 | 2.2E−08 |
| rs2106353 | 7 | 126,506,598 | T | G | 0.23 | 0.04 | 1.4E−10 |
| rs2145318 | 6 | 26,496,603 | A | T | 0.49 | 0.04 | 2.0E−13 |
| rs215614 | 7 | 32,347,335 | A | G | 0.63 | − 0.03 | 4.1E−11 |
| rs2164300 | 4 | 67,813,017 | T | C | 0.52 | − 0.03 | 4.1E−08 |
| rs2240326 | 3 | 50,128,386 | A | G | 0.47 | − 0.05 | 1.1E−22 |
| rs2358016 | 2 | 162,007,430 | G | C | 0.50 | 0.03 | 4.2E−09 |
| rs2396133 | 7 | 109,197,067 | G | A | 0.48 | 0.03 | 1.1E−09 |
| rs2396766 | 7 | 114,318,071 | A | G | 0.47 | 0.03 | 2.3E−11 |
| rs2734839 | 11 | 113,286,490 | T | C | 0.61 | − 0.03 | 8.8E−09 |
| rs2744961 | 6 | 34,655,000 | T | C | 0.36 | 0.03 | 5.8E−09 |
| rs2782641 | 1 | 44,013,355 | A | G | 0.61 | 0.03 | 4.3E−08 |
| rs2815749 | 1 | 72,814,783 | G | A | 0.80 | 0.04 | 1.1E−10 |
| rs2834005 | 21 | 34,291,708 | C | T | 0.32 | 0.03 | 9.4E−09 |
| rs2838771 | 21 | 46,501,576 | C | G | 0.65 | − 0.03 | 2.9E−08 |
| rs324769 | 12 | 83,969,240 | T | C | 0.45 | − 0.03 | 3.0E−08 |
| rs329122 | 5 | 133,864,599 | A | G | 0.42 | − 0.03 | 3.1E−09 |
| rs3766823 | 1 | 32,197,257 | A | G | 0.17 | 0.04 | 7.1E−10 |
| rs3793577 | 9 | 23,737,627 | G | A | 0.54 | 0.03 | 2.5E−08 |
| rs3828917 | 6 | 31,465,917 | T | G | 0.04 | 0.07 | 2.3E−08 |
| rs3863241 | 8 | 73,890,335 | T | C | 0.53 | 0.03 | 1.5E−11 |
| rs4300861 | 2 | 22,549,441 | T | C | 0.38 | 0.03 | 5.4E−10 |
| rs4382592 | 9 | 134,870,755 | G | T | 0.70 | − 0.03 | 8.2E−09 |
| rs4713692 | 6 | 33,807,638 | T | C | 0.37 | − 0.03 | 3.1E−08 |
| rs569356 | 1 | 29,136,686 | G | A | 0.14 | − 0.04 | 4.1E−08 |
| rs6711584 | 2 | 104,421,692 | A | G | 0.45 | 0.03 | 2.7E−11 |
| rs6722661 | 2 | 100,806,588 | A | G | 0.37 | − 0.03 | 1.1E−10 |
| rs6780459 | 3 | 104,624,105 | T | A | 0.75 | 0.03 | 3.1E−08 |
| rs7032155 | 9 | 122,672,771 | A | C | 0.59 | 0.03 | 1.6E−08 |
| rs7206608 | 16 | 82,872,628 | G | C | 0.32 | 0.03 | 1.5E−08 |
| rs7241572 | 18 | 77,580,712 | A | G | 0.21 | 0.04 | 9.5E−10 |
| rs7527682 | 1 | 189,172,684 | G | A | 0.54 | − 0.03 | 3.1E−08 |
| rs7541875 | 1 | 190,957,589 | G | A | 0.43 | 0.03 | 1.6E−08 |
| rs7600261 | 2 | 212,622,818 | T | C | 0.31 | 0.03 | 9.5E−11 |
| rs7612999 | 3 | 35,678,337 | A | G | 0.25 | 0.03 | 4.9E−08 |
| rs761777 | 10 | 134,938,075 | G | A | 0.25 | 0.04 | 4.7E−10 |
| rs7675588 | 4 | 80,734,978 | A | C | 0.80 | − 0.03 | 1.8E−08 |
| rs7685686 | 4 | 3,207,142 | G | A | 0.42 | − 0.03 | 1.1E−08 |
| rs773109 | 12 | 56,374,695 | A | G | 0.34 | − 0.04 | 8.7E−14 |
| rs7942368 | 11 | 76,465,362 | T | C | 0.22 | − 0.03 | 9.5E−09 |
| rs903678 | 1 | 201,809,918 | A | G | 0.34 | 0.03 | 4.9E−08 |
| rs903959 | 8 | 142,630,782 | A | T | 0.40 | 0.03 | 3.0E−09 |
| rs9372625 | 6 | 98,344,031 | A | G | 0.38 | − 0.04 | 2.6E−14 |
| rs9373363 | 6 | 143,150,043 | G | A | 0.25 | − 0.03 | 4.1E−09 |
| rs9396740 | 6 | 17,023,108 | A | G | 0.25 | − 0.03 | 1.5E−08 |
| rs942065 | 14 | 94,032,065 | A | G | 0.63 | 0.03 | 8.4E−10 |
| rs9517313 | 13 | 99,105,892 | C | G | 0.38 | 0.03 | 2.0E−11 |
| rs9529055 | 13 | 66,957,533 | A | G | 0.48 | 0.03 | 3.1E−08 |
| rs9542729 | 13 | 31,833,578 | G | C | 0.20 | − 0.04 | 1.4E−09 |
| rs957345 | 14 | 75,276,079 | G | C | 0.54 | 0.03 | 1.7E−09 |
| rs9615905 | 22 | 48,875,699 | T | C | 0.46 | 0.03 | 1.2E−08 |
| rs9636202 | 19 | 18,449,238 | A | G | 0.27 | − 0.04 | 1.5E−10 |
| rs9940128 | 16 | 53,800,754 | A | G | 0.42 | 0.03 | 8.1E−12 |
SNP, Single-nucleotidepolymorphism; Chr, Chromosome; EAF, Effect allele frequency
aChange in the GERD GWAS population