Table 3.

The 35 SNPs associated with SAS from a meta-analyses involving 5 cohorts that were available in the SAS and GERD GWAS and included in the MR analyses

SNP	Chr	Position	Effect Allele	Other Allele	EAF	βb	P
rs11075985	16	53,805,207	A	C	0.43	0.04	4.46E−24
rs10878269	12	65,791,463	T	C	0.33	0.03	3.86E−16
rs592333	13	51,340,315	G	A	0.53	− 0.03	1.69E−14
rs6265	11	27,679,916	T	C	0.18	− 0.04	1.79E−14
rs72902175	2	157,013,035	T	C	0.13	0.04	3.67E−14
rs2307111	5	75,003,678	C	T	0.59	0.03	1.53E−13
rs35445111	19	32,172,047	G	A	0.91	0.04	1.62E−11
rs11041997	11	8,602,016	A	G	0.54	0.02	3.42E−11
rs6113592	20	22,229,505	G	A	0.63	0.02	7.82E−11
rs12603115	17	46,248,994	T	C	0.58	− 0.02	8.14E−10
rs1444789	10	9,064,361	C	T	0.78	− 0.03	1.10E−09
rs1537818	1	39,647,038	A	G	0.7	− 0.02	1.31E−09
rs57222984	17	43,758,898	G	A	0.82	− 0.03	1.62E−09
rs11634019	15	76,634,680	C	T	0.71	0.02	1.84E−09
rs8176749	9	136,131,188	T	C	0.09	− 0.04	3.78E−09
rs227731	17	54,773,238	G	T	0.54	− 0.02	3.96E−09
rs4076077	5	170,863,509	T	C	0.49	− 0.02	4.26E−09
rs698408	7	127,345,936	A	G	0.32	0.02	4.61E−09
rs4987719	18	60,960,310	T	C	0.03	0.06	4.72E−09
rs1428381	5	122,693,901	G	A	0.29	0.02	4.83E−09
rs4923536	11	28,422,496	G	A	0.54	− 0.02	5.39E−09
rs34811474	4	25,408,838	A	G	0.23	− 0.02	6.50E−09
rs1403848	3	77,609,655	A	C	0.54	− 0.02	9.30E−09
rs7005777	8	78,233,600	T	G	0.75	0.02	1.12E−08
rs1007311	7	150,696,008	G	A	0.58	− 0.02	1.22E−08
rs8045335	16	60,607,116	G	A	0.42	− 0.02	1.24E−08
rs6842303	4	17,854,055	G	T	0.28	− 0.02	1.39E−08
rs2715039	7	84,094,964	C	A	0.6	− 0.02	2.04E−08
rs1815739	11	66,328,095	C	T	0.4	0.02	2.10E−08
rs6038517	20	6,458,205	G	A	0.74	− 0.02	2.19E−08
rs9933881	16	1,740,691	C	T	0.93	− 0.04	2.54E−08
rs10747478	1	96,901,455	G	T	0.41	− 0.02	2.90E−08
rs2601764	10	33,815,235	C	A	0.59	− 0.02	3.47E−08
rs6988053	8	71,546,963	T	C	0.44	0.02	4.47E−08
rs9551973	13	20,256,342	C	T	0.88	− 0.03	4.52E−08

SNP, Single-nucleotide polymorphism; Chr, Chromosome; EAF, Effect allele frequency

^bChange in the SAS GWAS population