Table 2.
Univariate and multivariate analyses for recurrence-free survival in 86 patients with atypical meningioma
| Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
| Parameter | HR (95% CI) | P | HR (95% CI) | P |
| Age | ||||
| ≤ 65 years | 1 | 0.975 | ||
| > 65 years | 1 (0.5–1.7) | |||
| Sex | ||||
| Male | 1 | 0.650 | ||
| Female | 0.8 (0.5–1.5) | |||
| Site | ||||
| Convexity | 1 | 0.0021 | 1 | |
| Parafalcine/tentorial | 1.7 (0.9–3.1) | 2.1 (1.1–4.1) | 0.0177 | |
| Skull base | 0.8 (0.4–1.6) | 1.7 (0.6–5.1) | 0.297 | |
| Ventricular | 13 (0-12186) | 10 (1.2–97.1) | 0.0316 | |
| Simpson grade | ||||
| 1 | 1 | 0.452 | ||
| 2 | 1.4 (0.7–2.8) | |||
| 3 | 1 (0.3–2.8) | |||
| Histological group | ||||
| Mitotically active | 2.7 (1.5–4.8) | 0.0054 | 1 | |
| Brain invasive otherwise benign | 1 | 0.2 (0.1–0.6) | 0.0036 | |
| Minor atypical criteria | 1.8 (0.7–4.7) | 0.7 (0.2–1.9) | 0.539 | |
| Immunohistochemical group | ||||
| Group 1 (ACADL-/MCM2-) | 1 | 0.0007 | 0.4 (0.2-1) | 0.0689 |
| Group 2 (ACADL+/MCM2-) | 2.5 (1.2–5.2) | 0.7 (0.3–1.6) | 0.529 | |
| Group 3 (MCM2+) | 3.6 (2-6.5) | 1 | ||
| NF2 mutation | ||||
| Absent | 1 | 0.794 | ||
| Present | 0.8 (0.3–2.1) | |||
| AKT1 mutation | ||||
| Absent | 1 | 0.882 | ||
| Present | 1.1 (0.2–5.3) | |||
| 1p deletion | ||||
| Absent | 1 | 0.0048 | 0.4 (0.2–0.9) | 0.0290 |
| Present | 2.3 (1.2–4.1) | 1 | ||
| 1p deletion/22q deletion | ||||
| 1pdel/22q non-del | 1 | 0.431 | ||
| 1p del/22q del | 1.7 (0.3–8.8) | |||
HZ: hazard ratio. C.I.: confidence interval. Del: deleted