Fig. 1.

A repository of neuroblastoma cell lines with detailed genetic and pharmacological annotation. (a) Oncoplot showing the genetic aberrations, TMM and adrenergic-mesenchymal score found in the panel of 19 neuroblastoma cell lines as detected by WGS and RNA-Seq (snv = single nucleotide variant, LOH = Loss Of Heterozygosity). (b) Heatmap showing the compound response profiles (AUC values) for the panel of 19 neuroblastoma cell lines. Only compounds are shown measured for all 19 cell lines and with at least one AUC below 450. AUC values are standardized by row. (c) Boxplots showing the response of the cell lines to idasanutlin treatment separated by TP53 status (WT = Wild Type; LOF = Loss Of Function). P value was determined with the Wilcoxon rank-sum test. (d) Fitted curves for the idasanutlin response of the panel of cell lines. The red curves indicate a TP53 wild type status, the blue curves a TP53 loss-of-function. (e) Plot showing the difference between the mean AUC of the cell line panel (excluding IMR32) and IMR32 (ΔAUC). A positive ΔAUC indicates an above average sensitivity of IMR32, a negative value a higher resistance. A selection of common targets is highlighted. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)