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. Author manuscript; available in PMC: 2025 Mar 6.
Published in final edited form as: Prog Neurobiol. 2017 Aug 24;163-164:59–78. doi: 10.1016/j.pneurobio.2017.08.002

Fig. 4.

Fig. 4.

miRNAs regulate neurogenesis and angiogenesis of post-stroke brain reorganization. miR-17-92 promotes neurogenesis through increased proliferation of neural progenitor cells following ischemic stroke. mR-124 decreases the ischemia-induced proliferation of neural progenitor cells by repressing Jagged-1 and the Notch signaling pathway. miR-210 promotes post-stroke neurogenesis by activating the Notch pathway. Several miRNAs, such as miR-210, -107, -140-5p and -376b-5p, modulate post-stroke angiogenesis by regulating the VEGF pathway. miR-155 and miR-124 promote the post-stroke angiogenesis targeting Rheb and REST, respectively. The activation and inhibition are indicated by an arrow line and a T-shape line, respectively.