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Effects of inhibitors on mitochondrial-nucleoid DNA synthesis
| Inhibitors | Mitochondrial-nucleoid DNA synthesis Percentage (%) | |
|---|---|---|
| 30 min | 60 min | |
| Control | 100 | 100 |
| Aphidicolin (20 μM) | 118 | 99 |
| Aphidicolin (40 μM) | 114 | 105 |
| Aphidicolin (100 μM) | 98.4 | 91.1 |
| NEM (2 mM) | 44 | 41.1 |
| NEM (10 mM) | 0.106 | 0.03 |
| ddCTP/dCTP (1:1) | 99 | 94.8 |
| ddCTP/dCTP (10:1) | 90 | 94.5 |
| ddCTP/dCTP (100:1) | 44.3 | 42.2 |
| ddCTP/dCTP (1000:1) | 11.3 | 13.5 |
Control represents 20 000–30 000 c.p.m. for each set of reactions.
