Table 1. Activity of quinoline and isoquinoline derivatives in in vitro kinase and cell-based assays.

Compound	Structures	% inhibition				IC50 (nM)
		EGFR		HER2		SKBR3
		1 μM	0.1 μM	1 μM	0.1 μM
4	a–e	90	59	92	62	1358
9a	a–f	91	56	92	55	235
9b	a–g	98	85	95	58	125
9c	a–h	76	32	80	40	3199
9d	a–i	59	22	73	30	4527
11a	b–d	69	16	91	50	1175
11b	b–e	87	33	86	32	725
11c	b–f	84	43	77	33	553
12a	c–d	68	10	92	56	1389
12b	c–e	61	9	88	44	610
12c	c–f	66	15	83	37	392
14a	c–g	92	54	92	43	103
Lapatinib		99	94	96	70	23