Table 8.

Binding affinity and amino acid residues.

Ligand	Binding affinity (kcal mol)	Hydrogen Bonds	Hydrophobic Bonds
Native ligand	−9,6	Asn332, Lys277, Gly331, His328, Ala326	Leu386, Val250, Val258, Ala275
Delphinidin 3-glucoside	−10,4	Lys277, Thr325, Ala256	Val258, Leu386, Val250, Leu305, Ala275, Cys396
Cyanidin 3-O-galactoside	−10,3	Asp397, Glu290, Lys277, Phe327	Leu386, Val258, Val250, Ala275, Leu305, Cys396
Cyanidin 3-glucoside	−10,2	Lys277, Asp397, Glu290, Phe327	Val258, Leu386, Val250, Ala275, Cys396, Leu305
Pelargonidin-3-glucoside	−9,8	Ala256, Asp397	Val258, Leu386, Ala275, Lys277, Leu305, Cys396, Val250
Peonidin 3-galactoside	−9,1	Asp397, Ser383, Thr325, Leu323	Leu386, Val250, Leu305, Lys277, Ala275, Cys396, Ala256, Val258, Asn332
Peonidin-3-glucoside	−9,1	Thr325, Ser383, Leu323, Gly253, Phe327	Leu386, Ala275, Cys396, Leu305, Lys277, Val250
Pirfenidone	−7,9	—	Leu 386, Val258, Ala275, Phe327, Leu305