Figure 2: PT-Cy impairs the size and diversity of the T-cell repertoire.

a, Global TCR repertoire diversity as measured by inverse Simpson diversity and Shannon entropy was calculated for graft samples (N=101). Comparisons between treatment arms were made using Mann-Whitney U tests. b, Global TCR repertoire diversity as measured by inverse Simpson diversity (left) and Shannon entropy (right) was calculated for each patient at each timepoint (N=324 patients). Log-normalized values were compared between arms using a mixed effects model for repeated measures testing, followed by Fisher’s least significant difference posttests at each timepoint. Asterisks indicate P values for these comparisons, * P<0.05, ** P<0.01, *** P<0.001.