TABLE E2.
Detailed results of multiple comparison testing between groups for each measured aortic segment
| Regurgitant fraction multiple comparisons by segment | |||||
|---|---|---|---|---|---|
|
| |||||
| Tukey’s multiple comparisons test | Mean difference | 95% CI of difference | Below threshold? | Summary | Adjusted P value |
|
| |||||
| STJ | |||||
| MFS vs LDS | 1.28 | −5.750 to 8.310 | No | ns | .8564 |
| MFS vs no aortopathy | 3.625 | −2.860 to 10.11 | No | ns | .2354 |
| LDS vs no aortopathy | 2.345 | −3.850 to 8.540 | No | ns | .3951 |
| Ascending aorta | |||||
| MFS vs LDS | −0.658 | −7.997 to 6.681 | No | ns | .961 |
| MFS vs no aortopathy | −2.696 | −17.21 to 11.82 | No | ns | .7988 |
| LDS vs no aortopathy | −2.038 | −16.48 to 12.41 | No | ns | .882 |
| Proximal arch | |||||
| MFS vs LDS | −2.213 | −13.68 to 9.258 | No | ns | .8348 |
| MFS vs no aortopathy | −3.63 | −20.03 to 12.77 | No | ns | .7599 |
| LDS vs no aortopathy | −1.418 | −18.13 to 15.29 | No | ns | .9604 |
| Distal arch | |||||
| MFS vs LDS | −4.534 | −20.27 to 11.21 | No | ns | .6733 |
| MFS vs no aortopathy | −4.924 | −31.63 to 21.78 | No | ns | .8083 |
| LDS vs no aortopathy | −0.39 | −27.11 to 26.33 | No | ns | .9987 |
| DAo LSA | |||||
| MFS vs LDS | 4.26 | −10.70 to 19.22 | No | ns | .6663 |
| MFS vs no aortopathy | 3.977 | −13.22 to 21.18 | No | ns | .7814 |
| LDS vs no aortopathy | −0.2825 | −15.25 to 14.69 | No | ns | .9978 |
| DAo PA | |||||
| MFS vs LDS | 5.634 | −12.22 to 23.49 | No | ns | .5833 |
| MFS vs no aortopathy | 9.992 | −7.850 to 27.83 | No | ns | .2705 |
| LDS vs no aortopathy | 4.358 | −5.557 to 14.27 | No | ns | .3927 |
| DAo Max | |||||
| MFS vs LDS | −4.905 | −20.06 to 10.25 | No | ns | .6202 |
| MFS vs no aortopathy | 0.7375 | −11.11 to 12.59 | No | ns | .9797 |
| LDS vs no aortopathy | 5.643 | −8.752 to 20.04 | No | ns | .4332 |
| Test details | Mean 1 | Mean 2 | Mean difference | SE of difference | N1 | N2 | q | DF |
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| STJ | ||||||||
| MFS vs LDS | 4.36 | 3.08 | 1.28 | 2.386 | 5 | 4 | 0.7586 | 6.987 |
| MFS vs no aortopathy | 4.36 | 0.735 | 3.625 | 1.861 | 5 | 4 | 2.755 | 4.202 |
| LDS vs no aortopathy | 3.08 | 0.735 | 2.345 | 1.55 | 4 | 4 | 2.139 | 3.222 |
| Ascending aorta | ||||||||
| MFS vs LDS | 3.422 | 4.08 | −0.658 | 2.441 | 5 | 4 | 0.3812 | 6.457 |
| MFS vs no aortopathy | 3.422 | 6.118 | −2.696 | 4.104 | 5 | 4 | 0.9289 | 4.069 |
| LDS vs no aortopathy | 4.08 | 6.118 | −2.038 | 4.207 | 4 | 4 | 0.6849 | 4.354 |
| Proximal arch | ||||||||
| MFS vs LDS | 5.81 | 8.023 | −2.213 | 3.81 | 5 | 4 | 0.8213 | 6.421 |
| MFS vs no aortopathy | 5.81 | 9.44 | −3.63 | 4.997 | 5 | 4 | 1.027 | 4.885 |
| LDS vs no aortopathy | 8.023 | 9.44 | −1.418 | 5.216 | 4 | 4 | 0.3843 | 5.228 |
| Distal arch | ||||||||
| MFS vs LDS | 8.726 | 13.26 | −4.534 | 5.179 | 5 | 4 | 1.238 | 6.203 |
| MFS vs no aortopathy | 8.726 | 13.65 | −4.924 | 7.724 | 5 | 4 | 0.9016 | 4.282 |
| LDS vs no aortopathy | 13.26 | 13.65 | −0.39 | 8.083 | 4 | 4 | 0.0682 | 4.79 |
| DAo LSA | ||||||||
| MFS vs LDS | 15.5 | 11.24 | 4.26 | 4.781 | 5 | 4 | 1.26 | 5.622 |
| MFS vs no aortopathy | 15.5 | 11.53 | 3.977 | 5.837 | 5 | 4 | 0.9635 | 6.984 |
| LDS vs no aortopathy | 11.24 | 11.53 | −0.2825 | 4.428 | 4 | 4 | 0.0902 | 4.521 |
| DAo PA | ||||||||
| MFS vs LDS | 14.85 | 9.22 | 5.634 | 5.369 | 5 | 4 | 1.484 | 4.716 |
| MFS vs no aortopathy | 14.85 | 4.863 | 9.992 | 5.757 | 5 | 4 | 2.455 | 5.799 |
| LDS vs no aortopathy | 9.22 | 4.863 | 4.358 | 3.028 | 4 | 4 | 2.035 | 4.912 |
| DAo Max | ||||||||
| MFS vs LDS | 9.9 | 14.81 | −4.905 | 5.075 | 5 | 4 | 1.367 | 6.62 |
| MFS vs no aortopathy | 9.9 | 9.163 | 0.7375 | 3.817 | 5 | 4 | 0.2732 | 5.766 |
| LDS vs no aortopathy | 14.81 | 9.163 | 5.643 | 4.123 | 4 | 4 | 1.935 | 4.188 |
| Peak velocity multiple comparisons by segment | |||||
|---|---|---|---|---|---|
|
| |||||
| Tukey’s multiple comparisons test | Mean difference | 95% CI of difference | Below threshold? | Summary | Adjusted P value |
|
| |||||
| STJ | |||||
| MFS vs LDS | 7.261 | −62.67 to 77.19 | No | ns | .9499 |
| MFS vs no aortopathy | −0.8815 | −66.24 to 64.48 | No | ns | .9991 |
| LDS vs no aortopathy | −8.142 | −65.12 to 48.84 | No | ns | .896 |
| Ascending aorta | |||||
| MFS vs LDS | −4.573 | −85.77 to 76.62 | No | ns | .981 |
| MFS vs no aortopathy | 54.18 | −28.64 to 137.0 | No | ns | .1636 |
| LDS vs no aortopathy | 58.76 | 31.12–86.39 | Yes | ** | .0038 |
| Proximal arch | |||||
| MFS vs LDS | −51.19 | −114.2 to 11.80 | No | ns | .0999 |
| MFS vs no aortopathy | 37.6 | −26.11 to 101.3 | No | ns | .2161 |
| LDS vs no aortopathy | 88.79 | 59.40–118.2 | Yes | *** | .0005 |
| Distal arch | |||||
| MFS vs LDS | −55.59 | −126.1 to 14.89 | No | ns | .103 |
| MFS vs no aortopathy | 31.67 | −38.63 to 102.0 | No | ns | .3618 |
| LDS vs no aortopathy | 87.26 | 67.21–107.3 | Yes | **** | <.0001 |
| DAo LSA | |||||
| MFS vs LDS | −63.89 | −118.7 to −9.096 | Yes | * | .0264 |
| MFS vs no aortopathy | −7.182 | −66.16 to 51.80 | No | ns | .9322 |
| LDS vs no aortopathy | 56.71 | 5.290–108.1 | Yes | * | .0344 |
| DAo PA | |||||
| MFS vs LDS | −33.82 | −70.54 to 2.895 | No | ns | .0687 |
| MFS vs no aortopathy | 2.102 | −43.53 to 47.74 | No | ns | .9894 |
| LDS vs no aortopathy | 35.92 | −8.923 to 80.77 | No | ns | .1042 |
| DAo max | |||||
| MFS vs LDS | −17.19 | −169.6 to 135.2 | No | ns | .9354 |
| MFS vs no aortopathy | 49.88 | −104.6 to 204.3 | No | ns | .5521 |
| LDS vs no aortopathy | 67.07 | −18.18 to 152.3 | No | ns | .0995 |
| Test details | Mean 1 | Mean 2 | Mean difference | SE of difference | N1 | N2 | q | DF |
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| STJ | ||||||||
| MFS vs LDS | 142.6 | 135.3 | 7.261 | 23.69 | 5 | 4 | 0.4334 | 6.935 |
| MFS vs no aortopathy | 142.6 | 143.5 | −0.8815 | 21.45 | 5 | 4 | 0.0581 | 6.148 |
| LDS vs no aortopathy | 135.3 | 143.5 | −8.142 | 18.06 | 4 | 4 | 0.6377 | 5.473 |
| Ascending aorta | ||||||||
| MFS vs LDS | 142.8 | 147.4 | −4.573 | 24.44 | 5 | 4 | 0.2646 | 4.726 |
| MFS vs no aortopathy | 142.8 | 88.6 | 54.18 | 23.54 | 5 | 4 | 3.255 | 4.115 |
| LDS vs no aortopathy | 147.4 | 88.6 | 58.76 | 7.666 | 4 | 4 | 10.84 | 3.905 |
| Proximal arch | ||||||||
| MFS vs LDS | 113 | 164.1 | −51.19 | 19.79 | 5 | 4 | 3.658 | 5.33 |
| MFS vs no aortopathy | 113 | 75.36 | 37.6 | 18.77 | 5 | 4 | 2.833 | 4.476 |
| LDS vs no aortopathy | 164.1 | 75.36 | 88.79 | 8.912 | 4 | 4 | 14.09 | 4.82 |
| Distal arch | ||||||||
| MFS vs LDS | 108.5 | 164.1 | −55.59 | 20.57 | 5 | 4 | 3.822 | 4.375 |
| MFS vs no aortopathy | 108.5 | 76.82 | 31.67 | 20.67 | 5 | 4 | 2.167 | 4.455 |
| LDS vs no aortopathy | 164.1 | 76.82 | 87.26 | 6.515 | 4 | 4 | 18.94 | 5.942 |
| DAo LSA | ||||||||
| MFS vs LDS | 86.63 | 150.5 | −63.89 | 18.33 | 5 | 4 | 4.928 | 6.605 |
| MFS vs no aortopathy | 86.63 | 93.81 | −7.182 | 20.02 | 5 | 4 | 0.5072 | 6.998 |
| LDS vs no aortopathy | 150.5 | 93.81 | 56.71 | 16.48 | 4 | 4 | 4.866 | 5.677 |
| DAo PA | ||||||||
| MFS vs LDS | 72.4 | 106.2 | −33.82 | 12.46 | 5 | 4 | 3.839 | 6.982 |
| MFS vs no aortopathy | 72.4 | 70.3 | 2.102 | 15.08 | 5 | 4 | 0.1971 | 6.304 |
| LDS vs no aortopathy | 106.2 | 70.3 | 35.92 | 14.06 | 4 | 4 | 3.614 | 5.293 |
| DAo Max | ||||||||
| MFS vs LDS | 139 | 156.2 | −17.19 | 49.1 | 5 | 4 | 0.4951 | 5.771 |
| MFS vs no aortopathy | 139 | 89.12 | 49.88 | 44.7 | 5 | 4 | 1.578 | 4.29 |
| LDS vs no aortopathy | 156.2 | 89.12 | 67.07 | 23.52 | 4 | 4 | 4.033 | 3.858 |
| Wall shear stress multiple comparisons by segment | |||||
|---|---|---|---|---|---|
|
| |||||
| Tukey’s multiple comparisons test | Mean difference | 95.00% CI of difference | Below threshold? | Summary | Adjusted P value |
|
| |||||
| STJ | |||||
| MFS vs LDS | 3.6 | −5.666 to 12.87 | No | ns | .4547 |
| MFS vs no aortopathy | 6.85 | −2.530 to 16.23 | No | ns | .1444 |
| LDS vs no aortopathy | 3.25 | −2.898 to 9.398 | No | ns | .2612 |
| Ascending aorta | |||||
| MFS vs LDS | 2.05 | −11.90 to 16.00 | No | ns | .8918 |
| MFS vs no aortopathy | 8.8 | −5.399 to 23.00 | No | ns | .1887 |
| LDS vs no aortopathy | 6.75 | −0.5873 to 14.09 | No | ns | .064 |
| Proximal arch | |||||
| MFS vs LDS | −5.15 | −14.53 to 4.230 | No | ns | .2906 |
| MFS vs no aortopathy | 7.85 | −1.368 to 17.07 | No | ns | .0843 |
| LDS vs no aortopathy | 13 | 6.898–19.10 | Yes | ** | .0027 |
| Distal arch | |||||
| MFS vs LDS | −8.25 | −22.10 to 5.604 | No | ns | .2332 |
| MFS vs no aortopathy | 6 | −2.739 to 14.74 | No | ns | .1528 |
| LDS vs no aortopathy | 14.25 | −0.5436 to 29.04 | No | ns | .0553 |
| DAo LSA | |||||
| MFS vs LDS | −8.55 | −20.32 to 3.224 | No | ns | .1486 |
| MFS vs no aortopathy | 3.2 | −5.985 to 12.38 | No | ns | .5647 |
| LDS vs no aortopathy | 11.75 | 0.5653–22.93 | Yes | * | .0425 |
| DAo PA | |||||
| MFS vs LDS | −6.15 | −18.64 to 6.343 | No | ns | .3614 |
| MFS vs no aortopathy | 3.1 | −6.529 to 12.73 | No | ns | .6078 |
| LDS vs no aortopathy | 9.25 | −2.698 to 21.20 | No | ns | .1072 |
| DAo max | |||||
| MFS vs LDS | −3.3 | −21.82 to 15.22 | No | ns | .8618 |
| MFS vs no aortopathy | 8.45 | −8.409 to 25.31 | No | ns | .3305 |
| LDS vs no aortopathy | 11.75 | −3.380 to 26.88 | No | ns | .1105 |
| Test details | Mean 1 | Mean 2 | Mean difference | SE of difference | N1 | N2 | q | DF |
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| STJ | ||||||||
| MFS vs LDS | 19.6 | 16 | 3.6 | 2.75 | 5 | 4 | 1.852 | 4.556 |
| MFS vs no aortopathy | 19.6 | 12.75 | 6.85 | 3.102 | 5 | 4 | 3.123 | 6.32 |
| LDS vs no aortopathy | 16 | 12.75 | 3.25 | 1.75 | 4 | 4 | 2.626 | 4.128 |
| Ascending aorta | ||||||||
| MFS vs LDS | 22.8 | 20.75 | 2.05 | 4.45 | 5 | 4 | 0.6515 | 5.589 |
| MFS vs no aortopathy | 22.8 | 14 | 8.8 | 4.091 | 5 | 4 | 3.042 | 4.245 |
| LDS vs no aortopathy | 20.75 | 14 | 6.75 | 2.016 | 4 | 4 | 4.736 | 3.826 |
| Proximal arch | ||||||||
| MFS vs LDS | 19.6 | 24.75 | −5.15 | 3.102 | 5 | 4 | 2.348 | 6.32 |
| MFS vs no aortopathy | 19.6 | 11.75 | 7.85 | 2.791 | 5 | 4 | 3.978 | 4.801 |
| LDS vs no aortopathy | 24.75 | 11.75 | 13 | 1.814 | 4 | 4 | 10.13 | 4.579 |
| Distal arch | ||||||||
| MFS vs LDS | 19 | 27.25 | −8.25 | 4.419 | 5 | 4 | 2.64 | 5.587 |
| MFS vs no aortopathy | 19 | 13 | 6 | 2.608 | 5 | 4 | 3.254 | 4.621 |
| LDS vs no aortopathy | 27.25 | 13 | 14.25 | 3.705 | 4 | 4 | 5.439 | 3.226 |
| DAo LSA | ||||||||
| MFS vs LDS | 18.2 | 26.75 | −8.55 | 3.937 | 5 | 4 | 3.071 | 6.588 |
| MFS vs no aortopathy | 18.2 | 15 | 3.2 | 2.99 | 5 | 4 | 1.514 | 5.976 |
| LDS vs no aortopathy | 26.75 | 15 | 11.75 | 3.25 | 4 | 4 | 5.113 | 4.329 |
| DAo PA | ||||||||
| MFS vs LDS | 16.6 | 22.75 | −6.15 | 4.17 | 5 | 4 | 2.086 | 6.542 |
| MFS vs no aortopathy | 16.6 | 13.5 | 3.1 | 3.121 | 5 | 4 | 1.405 | 5.891 |
| LDS vs no aortopathy | 22.75 | 13.5 | 9.25 | 3.437 | 4 | 4 | 3.806 | 4.228 |
| DAo max | ||||||||
| MFS vs LDS | 24.2 | 27.5 | −3.3 | 6.284 | 5 | 4 | 0.7427 | 6.975 |
| MFS vs no aortopathy | 24.2 | 15.75 | 8.45 | 5.367 | 5 | 4 | 2.227 | 5.551 |
| LDS vs no aortopathy | 27.5 | 15.75 | 11.75 | 4.562 | 4 | 4 | 3.642 | 4.748 |
DAo, Distal aorta; LDS, Loeys-Dietz syndrome; LSA, left subclavian artery; MFS, Marfan syndrome; PA, pulmonary artery; STJ, sinotubular junction.
*
P < .05
**
P < .01
***
P < .001
****
P < .0001.