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. 2025 Jan 23;28(3):111873. doi: 10.1016/j.isci.2025.111873

Figure 7.

Figure 7

Identified proteasome-generated public Omicron SARS-CoV-2 RBD epitopes have global physiological relevance

(A) Crystal structure of Omicron RBD-hACE2 complex with marked regions containing public Omicron SARS-CoV-2 RBD epitopes. RBD amino acids crucial for patch 2 of the RBD-hACE2 binding interface are shown.

(B and C) Correlation between COVID-19 mortality and percentage of haplotypes (B) and population frequency of haplotypes (C) positive toward public Omicron SARS-CoV-2 RBD epitopes in different countries according to Spearman’s rank correlation. Omicron mutations are shown in bold.

(D) Analysis of population haplotype protective index and HLA-class I-positive haplotypes frequency toward RBD503-513 core epitope in different countries.

(E) COVID-19 mortality rate and vaccination status in Republic of Paraguay and geographically proximal Plurinational State of Bolivia in South America.

(F) Mortality rate, confirmed COVID-19 cases, and vaccination dynamics in Paraguay and Bolivia since March, 2020 till beginning of 2023. Confirmed cases and mortality are reported for periods from March, 2020 till beginning of December, 2021 (light gray) and for first Omicron wave 12.06.2021–03.07.2022 (gray).