Table 3.

Summary of Considerations for Biopsy Sampling of Peripheral Nerve Sheath Tumors Arising in the Setting of Neurofibromatosis Type 1

Preprocedure imaging considerations
Targeting of radiologically concerning but surgically accessible areas, multiple regions if possible
Sampling considerations
Use 14G to 18 G biopsy needles
Obtain at least 6 core biopsies if feasible
Clearly label separate containers with biopsy site of origin (eg, region #1, FDG-PET avid region)
Tissue processing considerations
No more than 2 cores per formalin-fixed, paraffin-embedded block
Evaluation by subspecialized pathologist