Table 4.

Example Pathology Reports Incorporating Standardized Set of Histologic Features

NF	Ulnar nerve, mass, and biopsy: plexiform neurofibroma, see comment. Comment: this tumor demonstrates retained neurofibroma architecture without cytologic atypia or hypercellularity. Mitotic figures are inconspicuous.
ANNUBP	Brachial plexus, mass, biopsy: atypical neurofibromatous neoplasm of uncertain biologic potential, see comment. Comment: this tumor demonstrates cytologic atypia, hypercellularity, and focal loss of neurofibroma architecture. Mitotic figures are inconspicuous.
ANNUBP with increased proliferation	Femoral nerve, mass, biopsy: atypical neurofibromatous neoplasm of uncertain biologic potential, see comment. Comment: this tumor does not demonstrate cytologic atypia, hypercellularity, or necrosis. However, focal loss of neurofibroma architecture is noted and the mitotic count reaches 5 mitotic figures per 10 HPFs focally.
MPNST	Sciatic nerve, mass, resection: MPNST, see comment. Comment: This hypercellular tumor is composed of enlarged and atypical tumor cells arranged in fascicles. No well-preserved neurofibroma architecture is noted. Large areas of necrosis are present. The mitotic count reaches 13 mitotic figures per 10 HPFs.

ANNUBP = atypical neurofibromatous neoplasm of uncertain biologic potential; HPFs = high-power fields; MPNST = malignant peripheral nerve sheath tumors; NF = neurofibroma.