Table 1.
Summary of enzymes known to remodel nucleosomes at the 5’ LTR
| Mechanism | Effect on HIV-1 Transcription | Factor | Cofactor | Target histone/residue | Cell line(s) used | Reference(s) |
|---|---|---|---|---|---|---|
| Nucleosome remodeling | Repressive | BRG1-BAF | BRD4S | nuc-0, nuc-1 | J-Lat 11.1/A2, Jurkat 1G5 | [80, 81] |
| HEK293T, J-Lat A2/A72 | [93] | |||||
| FACT | ? | nuc-1/H2A/H2B | 293T, A2, MT-2, primary CD4+ | [106] | ||
| Activating | BRM-BAF | Tat | nuc-1 | HEK293, HeLa/LTR-luc/S3 | [94] | |
| 293FT, A204, AZ521, C33A, H1299, S3, SW13, primary CD4+ | [95] | |||||
| PBAF | Tat-ac | nuc-1 | A2/11.1, 1G5 | [80, 81] | ||
| J1.1, Jurkat | [91] | |||||
| C33A, Jurkat | [97] | |||||
| 293T, CEM, HCC1143, TZM-bl | [98] | |||||
| 8E5, ACH2, HLM-1 | [99] | |||||
| A2/A72, C33A, G401, HCT116, MON, Jurkat | [100] |