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. 2025 Feb 28;11(1):12–17. doi: 10.52601/bpr.2024.240030

Table 2. Secretion of inflammatory cytokines by cultured monocytes.

Cytokine secretion (pg/mL) With premature CAD (n = 38) Without CAD (n = 35) р
CAD: coronary artery disease; TNF-α: tumor necrosis factor alpha; IL-1β: interleukin-1β; IL-6: interleukin-6; IL-8: interleukin-8; MCP-1: monocyte chemotactic protein-1. Data are presented as median and first and third quartiles (Me [Q1; Q3]).
TNF-α
Basal secretion 228 [216; 239] 192 [138; 213] <0.001
1 LPS stimulation (2nd day) 3780 [2801; 5882] 3578 [2376; 4694] 0.25
2 LPS stimulation (6th day) 239 [215; 289] 186 [151; 206] <0.001
IL-1β
Basal secretion 181 [134; 194] 110 [104; 154] <0.001
1 LPS stimulation (2nd day) 1536 [968; 1890] 858 [724; 1070] <0.001
2 LPS stimulation (6th day) 108 [93; 118] 87 [71; 101] 0.001
IL-6
Basal secretion 327 [303; 451] 301 [271; 370] 0.006
1 LPS stimulation (2nd day) 27879 [8674; 40646] 33397 [26839; 37803] 0.136
2 LPS stimulation (6th day) 1213 [1101; 2114] 1542 [1070; 2077] 0.833
IL-8
Basal secretion 7057 [4840; 9102] 5910 [4555; 7805] 0.200
1 LPS stimulation (2nd day) 202035 [182065; 212726] 162656 [147135; 212360] 0.09
2 LPS stimulation (6th day) 20111 [12130; 23951] 20217 [12769; 28073] 0.649
МСР-1
Basal secretion 3092 [2103; 4771] 1923 [1486; 2539] <0.001
1 LPS stimulation (2nd day) 39240 [16253; 70233] 31526 [20192; 55952] 0.624
2 LPS stimulation (6th day) 10173 [2813; 23221] 2910 [1764; 4097] 0.003