Fig. 7.

BoNT/A intoxication is prevented by administering VHH in mice model. Lethality of BoNT/A intoxication was monitored by administration of HM. Mice (n = 5) were exposed to 2 LD₅₀ of BoNT/A in a series of HM, (A) 0.25 mg/kg-5 mg/kg, (B) 50 μg/kg-200 μg/kg, and mice in all groups could be protected. (C) Survival of mice administered HM with high dose of 10 mg/kg, and challenged with a series of lethal dose of BoNT/A (2 LD₅₀, 20 LD₅₀, 200 LD₅₀).