Table 2. Clinical outcome in the overall population and according to the number of positive COVADIS criteria observed during acetylcholine provocation testing.

Characteristics	Overall population (n=519)	0 COVADIS criteria (n=127)	1 COVADIS criterion (n=87)	2 COVADIS criteria (n=117)	3 COVADIS criteria (n=188)	p-value
MACCE	53 (10.2)	4 (3.1)	8 (9.2)	12 (10.3)	29 (15.4)	0.004*
CV death	4 (0.8)	2 (1.6)	0 (0)	0 (0)	2 (1.1)	0.429
Non-fatal MI	8 (1.5)	0 (0)	1 (1.1)	4 (3.4)	3 (1.6)	0.265
Hospitalisation for UA	39 (7.5)	2 (1.6)	6 (6.9)	9 (7.7)	22 (11.7)	0.007*
Stroke/TIA	4 (0.8)	0 (0)	1 (1.1)	1 (0.9)	2 (1.1)	0.670
Recurrent angina	153 (29.5)	24 (18.9)	19 (21.8)	41 (35.0)	69 (36.7)	0.004*
SAQ summary score	84 [75;100]	88 [76; 100]	86 [78; 100]	84 [74; 90]	82 [72; 92]	0.037*
Follow-up time, months	22 [13; 30]	22 [13; 30]	23 [13; 31]	22 [12; 30]	21 [13; 30]	0.997
Values are expressed as n (%) or median [IQR]. *Indicates statistical significance. COVADIS: Coronary Vasomotor Disorders International Study Group; CV: cardiovascular; IQR: interquartile range; MACCE: major adverse cardiovascular and cerebrovascular events; MI: myocardial infarction; SAQ: Seattle Angina Questionnaire; TIA: transient ischaemic attack; UA: unstable angina