Table 3. Predictors of MACCE in the overall population by univariable and multivariable Cox regression analysis.

Predictors of MACCE	Univariable analysis		Multivariable analysis
	HR (95% CI)	p-value	HR (95% CI)	p-value
Typical anginal symptoms during ACh provocation testing	2.199 (1.129-4.281)	0.020*	0.921 (0.415-2.644)	0.921
Ischaemic ECG changes during ACh provocation testing	2.270 (1.191-4.330)	0.013*	1.165 (0.474-2.861)	0.739
Epicardial coronary diameter reduction ≥90%	2.775 (1.539-5.004)	0.001*	2.044 (1.064-3.924)	0.032*
MINOCA as clinical presentation	1.951 (1.132-3.363)	0.016*	1.892 (1.093-3.275)	0.023*
Beta blocker therapy at discharge	0.492 (0.253-0.958)	0.037*	0.601 (0.306-1.179)	0.139
CCB therapy at discharge	2.585 (1.260-5.304)	0.010*	1.617 (0.700-3.735)	0.261
*Indicates statistical significance. All the characteristics shown in Table 1 were tested to predict MACCE at follow-up, although only variables with a p-value<0.05 have been shown in this table. Variables that were significantly (p<0.05) related to MACCE at follow-up on univariable Cox regression analysis were included in the multivariable Cox regression analysis. ACh: acetylcholine; CCB: calcium channel blocker; CI: confidence interval; ECG: electrocardiogram; HR: hazard ratio; MACCE: major adverse cardiovascular and cerebrovascular events; MINOCA: myocardial infarction with non-obstructive coronary arteries