Table 2.
Correlation of CYP19 gene rs7176005 C/T SNP and rs6493497 G/A SNP to susceptibility of PCOS
| Locus | Genotype | Control (n = 340) |
PCOS (n = 340) |
P a | OR(95%CI)b | P c | adjusted OR(95%CI)d |
|---|---|---|---|---|---|---|---|
| rs7176005 | |||||||
| CC | 178(52.4) | 223(65.6) | |||||
| CT | 129(37.9) | 110(32.4) | 0.019 | 0.681(0.493–0.939) | 0.014 | 0.650(0.460–0.917) | |
| TT | 33(9.7) | 7(2.0) | 0.000 | 0.169(0.073–0.392) | 0.000 | 0.158(0.066–0.376) | |
| CT + TT | 162(47.6) | 117(34.4) | 0.000 | 0.576(0.423–0.785) | 0.000 | 0.545(0.391–0.759) | |
| C allele | 485(71.3) | 556(81.8) | |||||
| T allele | 195(28.7) | 124(18.2) | 0.000 | 0.555(0.429–0.716) | |||
| rs6493497 | |||||||
| GG | 178(52.4) | 223(65.6) | |||||
| GA | 129(37.9) | 110(32.4) | 0.019 | 0.681(0.493–0.939) | 0.014 | 0.650(0.460–0.917) | |
| AA | 33(9.7) | 7(2.0) | 0.000 | 0.169(0.073–0.392) | 0.000 | 0.158(0.066–0.376) | |
| GA + AA | 162(47.6) | 117(34.4) | 0.000 | 0.576(0.423–0.785) | 0.000 | 0.545(0.391–0.759) | |
| G allele | 485(71.3) | 556(81.8) | |||||
| A allele | 195(28.7) | 124(18.2) | 0.000 | 0.555(0.429–0.716) |
p-Value < 0.05 is considered as significant
OR,odds ratio; CI,confidence interval
a, Two-sided χ2 test; b, Unconditional logistic regression models; c, Two-sidedχ2 test with the adjustment for age, BMI; d, Unconditional logistic regression models with the adjustment for age, BMI