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. 2024 Sep 10;11(41):2404510. doi: 10.1002/advs.202404510

Figure 4.

Figure 4

Tumor microenvironment of SS subtypes: a–c) The distributions of immune and stroma cell types across SS subtypes by three deconvolutional approaches, including a) ESTIMATE, b) CIBERSORT, and c) MCPCounter, respectively, Middle line: median; box edges: 25th and 75th percentiles. Kruskal‐Wallis test. d) Heatmap of the three SS subtypes on the mRNA levels of 23 inhibitory and 36 stimulatory immune checkpoints. Clinicopathological characteristics (top) of the 55 SS patients are shown in the annotation, and different colors represent the characteristics and subtypes. The statistical differences in categorical variables were compared using the Fisher's exact test; Continues variables were compared using Kruskal‐Wallis test. *p < 0.05, **p < 0.01, ***p < 0.001. e,f) Distributions of the gene expressions of CD274 e) and PDCD1 f) in three synovial sarcoma subtypes. Middle line: median; box edges: 25th and 75th percentiles. Mann‐Whitney U test. g–i) Distributions of the T cell exclusion, dysfunction, and TIDE score in three SS subtypes. Middle line: median; box edges: 25th and 75th percentiles. Mann‐Whitney U test.