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. 2025 Mar 6;18:1081–1094. doi: 10.2147/JPR.S503743

Table 5.

Risk Classes and Predicted Probabilities of NSAID-Induced Cardiovascular Events

 Risk Class Risk Index Score (Points) All Patients (n=2551637), n(%)* Average Predicted Probability (95% CI) Observed Incidence
 1 0–50 1,811,997 (71.0) 0.03 (0.03, 0.03) 0.02
 2 51–58 409,312 (16.0) 0.14 (0.14, 0.14) 0.14
 3 59–63 137,973 (5.4) 0.24 (0.24, 0.24) 0.26
 4 64–68 77,499 (3.0) 0.34 (0.34, 0.34) 0.39
 5 69–72 37,932 (1.5) 0.46 (0.46, 0.46) 0.49
 6 73–76 27,188 (1.1) 0.55 (0.55, 0.55) 0.55
 7 77–80 18,131 (0.7) 0.65 (0.65, 0.65) 0.60
 8 81–85 15,088 (0.6) 0.74 (0.74, 0.74) 0.64
 9 86–93 11,443 (0.4) 0.84 (0.83, 0.84) 0.69
 10 ≥94 5,074 (0.2) 0.93 (0.93, 0.93) 0.75

Notes: *Percentage total not equal to 100 due to rounding. Model Performance. C-Statistic=0.88.