Table 1.

Infection grading.

Classification of Infection
Level of severity	Symptoms and signs	Treatment	Grade
Low-grade soft tissue infection	Cellulitis with signs of inflammation (redness, swelling, warmth, stinging pain, pain that increases on loading, tense)	Oral antibiotics Parenteral antibiotics Surgical intervention	1 1A 1B 1C
High-grade soft tissue infection	Pus collection, purulent discharge, raised level of C-reactive protein	Oral antibiotics Parenteral antibiotics Surgical intervention	2 2A 2B 2C
Bone infection	Radiographic evidence of osteitis (periosteal bone reaction), radiographic evidence of osteomyelitis (sequestrum and involucrum)	Oral antibiotics Parenteral antibiotics Surgical intervention	3 3A 3B 3C
Implant failure	Radiographic evidence of loosening	Parenteral antibiotics, explantation	4

Reprinted with permission from Wolters Kluwer Health, Inc. Journal of Bone & Joint Surgery. Safety of osseointegrated implants for transfemoral amputees: a two-center prospective cohort study. Munjed Al Muderis, Aditya Khemka, Sara J. Lord, et al. 2016;98(11).