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. 2005 Aug 15;102(34):12005–12010. doi: 10.1073/pnas.0505294102

Fig. 3.

Fig. 3.

Susceptibility of WT and CypD-deficient MEFs to apoptotic stimuli. (A) Susceptibility of MEFs to apoptotic death by mitochondria-dependent intrinsic signals. WT and CypD KO MEFs were treated with 1 μM staurosporine or 100 μM etoposide for 24 and 48 h. (B) Susceptibility to apoptotic cell death induced by ER stresses. WT and CypD KO MEFs were treated with thapsigargin (2 μM), tunicamycin (5 μg/μl), or brefeldin A (2 μM) for 24 and 48 h. (C) Susceptibility to apoptotic death by mitochondria-independent extrinsic stimuli. WT and CypD KO MEFs were treated with TNFα (1 ng/ml) or TNF-related apoptosis-inducing ligand (TRAIL) (1 μg/μl) in the presence of actinomycin D (2 μg/μl) for 12 and 16 h. (D) Susceptibility of WT and CypD-deficient MEFs to cell death induced by H2O2 (1 mM) for 16 and 20 h (*, P < 0.05). All error bars show SD.