Table 1. Patient characteristics of FUSCC HR+HER2− breast cancer cohort among recurrence group.
| Variables | n (%) | P | ||||
| Overall (N=314) |
No relapse (N=201) |
Primary resistant (N=49) |
Secondary resistant (N=41) |
Endocrine sensitive (N=23) |
||
| FUSCC, Fudan University Shanghai Cancer Center; HR, hormone receptor; HER2, human epidermal growth factor receptor 2; ER, estrogen receptor; IDC, infiltrating ductal carcinoma; HER2-low, HER2 immunohistochemistry 1+ or HER2 IHC 2+ with in situ hybridization (−); LVI, lymphovascular invasion; SNF, similarity network fusion. | ||||||
| Age (year) | 0.006 | |||||
| ≤50 | 142 (45.2) | 87 (43.3) | 29 (59.2) | 22 (53.7) | 4 (17.4) | |
| >50 | 172 (54.8) | 114 (56.7) | 20 (40.8) | 19 (46.3) | 19 (82.6) | |
| Menopause | 0.121 | |||||
| Premenopause | 137 (43.6) | 84 (41.8) | 25 (51.0) | 22 (53.7) | 6 (26.1) | |
| Postmenopausal | 176 (56.1) | 117 (58.2) | 24 (49.0) | 18 (43.9) | 17 (73.9) | |
| Unknown | 1 (0.3) | 0 (0) | 0 (0) | 1 (2.4) | 0 (0) | |
| Laterality | 0.625 | |||||
| Left | 166 (52.9) | 104 (51.7) | 30 (61.2) | 21 (51.2) | 11 (47.8) | |
| Right | 148 (47.1) | 97 (48.3) | 19 (38.8) | 20 (48.8) | 12 (52.2) | |
| Histology | 0.201 | |||||
| IDC | 293 (93.3) | 184 (91.5) | 47 (95.9) | 41 (100) | 21 (91.3) | |
| Others | 21 (6.7) | 17 (8.5) | 2 (4.1) | 0 (0) | 2 (8.7) | |
| pT | <0.001 | |||||
| pT1 | 132 (42.0) | 106 (52.7) | 14 (28.6) | 10 (24.4) | 2 (8.7) | |
| pT2 | 175 (55.7) | 93 (46.3) | 32 (65.3) | 31 (75.6) | 19 (82.6) | |
| pT3 | 6 (1.9) | 2 (1.0) | 2 (4.1) | 0 (0) | 2 (8.7) | |
| Unknown | 1 (0.3) | 0 (0) | 1 (2.0) | 0 (0) | 0 (0) | |
| pN | <0.001 | |||||
| pN0 | 125 (39.8) | 103 (51.2) | 8 (16.3) | 11 (26.8) | 3 (13.0) | |
| pN1 | 94 (29.9) | 59 (29.4) | 10 (20.4) | 16 (39.0) | 9 (39.1) | |
| pN2 | 52 (16.6) | 29 (14.4) | 14 (28.6) | 5 (12.2) | 4 (17.4) | |
| pN3 | 43 (13.7) | 10 (5.0) | 17 (34.7) | 9 (22.0) | 7 (30.4) | |
| Grade | 0.216 | |||||
| Grade I | 3 (1.0) | 3 (1.5) | 0 (0) | 0 (0) | 0 (0) | |
| Grade II | 195 (62.1) | 135 (67.2) | 26 (53.1) | 23 (56.1) | 11 (47.8) | |
| Grade III | 88 (28.0) | 49 (24.4) | 17 (34.7) | 12 (29.3) | 10 (43.5) | |
| Unknown | 28 (8.9) | 14 (7.0) | 6 (12.2) | 6 (14.6) | 2 (8.7) | |
| HER2 status | 0.060 | |||||
| HER2-0 | 59 (18.8) | 31 (15.4) | 15 (30.6) | 9 (22.0) | 4 (17.4) | |
| HER2-low | 237 (75.5) | 163 (81.1) | 34 (69.4) | 32 (78.0) | 8 (34.8) | |
| Unknown | 18 (5.7) | 7 (3.5) | 0 (0) | 0 (0) | 11 (47.8) | |
| ER status | 0.029 | |||||
| ER>10% | 266 (84.7) | 201 (100) | 24 (49.0) | 22 (53.7) | 19 (82.6) | |
| ER 1%−10% | 3 (1.0) | 0 (0) | 2 (4.1) | 0 (0) | 1 (4.3) | |
| Unknown | 45 (14.3) | 0 (0) | 23 (46.9) | 19 (46.3) | 3 (13.0) | |
| PR status | 0.192 | |||||
| PR>10% | 216 (68.8) | 164 (81.6) | 20 (40.8) | 17 (41.5) | 15 (65.2) | |
| PR 1%−10% | 36 (11.5) | 21 (10.4) | 6 (12.2) | 4 (9.8) | 5 (21.7) | |
| Unknown | 62 (19.7) | 16 (8.0) | 23 (46.9) | 20 (48.8) | 3 (13.0) | |
| Ki-67 status | 0.528 | |||||
| Ki-67>25% | 152 (48.4) | 96 (47.8) | 24 (49) | 19 (46.3) | 13 (56.5) | |
| Ki-67≤25% | 155 (49.4) | 105 (52.2) | 21 (42.9) | 20 (48.8) | 9 (39.1) | |
| Unknown | 7 (2.2) | 0 (0) | 4 (8.2) | 2 (4.9) | 1 (4.3) | |
| LVI | <0.001 | |||||
| Yes | 166 (52.9) | 84 (41.8) | 39 (79.6) | 27 (65.9) | 16 (69.6) | |
| No | 146 (46.5) | 116 (57.7) | 10 (20.4) | 13 (31.7) | 7 (30.4) | |
| Unknown | 2 (0.6) | 1 (0.5) | 0 (0) | 1 (2.4) | 0 (0) | |
| SNF subtype | <0.001 | |||||
| SNF1 | 50 (15.9) | 36 (17.9) | 5 (10.2) | 7 (17.1) | 2 (8.7) | |
| SNF2 | 51 (16.2) | 29 (14.4) | 14 (28.6) | 3 (7.3) | 5 (21.7) | |
| SNF3 | 71 (22.6) | 40 (19.9) | 10 (20.4) | 13 (31.7) | 8 (34.8) | |
| SNF4 | 35 (11.1) | 13 (6.5) | 12 (24.5) | 8 (19.5) | 2 (8.7) | |
| Unknown | 107 (34.1) | 83 (41.3) | 8 (16.3) | 10 (24.4) | 6 (26.1) | |
| PAM50 subtype | <0.001 | |||||
| Basal | 12 (3.8) | 8 (4.0) | 1 (2.0) | 3 (7.3) | 0 (0) | |
| HER2 | 13 (4.1) | 8 (4.0) | 2 (4.1) | 1 (2.4) | 2 (8.7) | |
| LumA | 98 (31.2) | 86 (42.8) | 4 (8.2) | 4 (9.8) | 4 (17.4) | |
| LumB | 99 (31.5) | 81 (40.3) | 3 (6.1) | 6 (14.6) | 9 (39.1) | |
| Normal | 17 (5.4) | 12 (6.0) | 2 (4.1) | 3 (7.3) | 0 (0) | |
| Unknown | 75 (23.9) | 6 (3.0) | 37 (75.5) | 24 (58.5) | 8 (34.8) | |