Figure 1.

Developmental lineage of neural crest cells. Neural crest cells differentiate into sympathogonia, which further develop into pheochromoblasts or neuroblasts. Pheochromoblasts give rise to chromaffin cells, which can form pheochromocytoma when located in the adrenal medulla or paraganglioma when these cells are extra-adrenal. Neuroblasts can mature into neurons of sympathetic ganglia or form neuroblastomas if they undergo neoplastic transformation. In some cases, neuroblastomas can mature into ganglioneuromas.