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. 2025 Jan 23;29(3):249–258. doi: 10.1007/s10157-024-02606-3

Table 4.

Correction rates of serum [Na+] (modified from previous studies [10, 12])

U.S. Recommendations European Guideline
Acute/symptomatic (moderate-to-severe)

Goal: + 4 to 6 mmol/L/d

Upper correction limit: none

Goal: + 5 mmol/L/d

Upper correction limit: + 10 mmol/L/d

Chronic/asymptomatic or symptomatic (minimal/mild)

Goals: + 4 to 8 mmol/L/d, + 4 to 6 mmol/L/d (ODS high risk)

Upper correction limits: + 10 to 12 mmol/L/d, + 8 mmol/L/d (ODS high risk)

Goal: none

Upper correction limit: + 10 mmol/L/d

Abbreviations: ODS osmotic demyelination syndrome