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. Author manuscript; available in PMC: 2025 Mar 11.
Published in final edited form as: Leukemia. 2024 Mar 1;38(5):981–990. doi: 10.1038/s41375-024-02194-x

Figure 2. Transcriptome profiling of PICALM::MLLT10-positive samples and the comparison between PICALM::MLLT10-positive acute leukemia subgroups.

Figure 2.

(A) Distribution of samples based on principal components (PCA) derived from expression data from RNA sequencing. Each dot represents one sample, and colors represent diagnosis. (B) Heatmap with hierarchical clustering across rows and columns showing row-normalized, z-score standardized expression levels (TPM) of significantly differentially expressed genes in each PICALM::MLLT10-positive acute leukemia subgroups in comparison to HSCs. Annotations in the upper panel refer to the expression of selected immunophenotypic markers corresponding to each sample evaluated by flow cytometry analysis. Diagnosis is depicted as colored segments that frame the top and bottom of the heatmap. (C) Pathway enrichment analysis for MSigDB Hallmarks gene sets. The 5 enriched pathways with highest significance are shown. Adjusted p-values are represented within color scale.