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. 2025 Mar 11;15:8429. doi: 10.1038/s41598-025-90116-x

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© The Author(s) 2025

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 1 — Group comparison of regional brain perfusion. Results of the general linear models comparing regional early-phase DAT PET uptake after controlling for age, sex, and education. The color scale indicates effect size (r-score) and white line demarcates statistically significant regions after multiple comparisons correction (P < 0.05, false discovery rate). DAT PET, dopamine transporter positron emission tomography; HC, healthy control; lvPPA, logopenic primary progressive aphasia; lvPPA^A−, amyloid-negative logopenic primary progressive aphasia; lvPPA^A+, amyloid-positive logopenic primary progressive aphasia. The image was generated using the SurfStat toolbox (http://www.math.mcgill.ca/keith/surfstat).