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. 2025 Mar 12;10:84. doi: 10.1038/s41392-025-02166-2

Table 5.

Preclinical studies of targeting other molecular chaperones

Compound Structure Activity Mechanism (Sites)
Compound 2H graphic file with name 41392_2025_2166_Tabbp_HTML.gif cIC50 = 5.0 µM HSP110 Inhibitor (/)
iHSP110-33 graphic file with name 41392_2025_2166_Tabbq_HTML.gif bIC50 = 58 μM HSP110 Inhibitor (NBD)
GdnHCl graphic file with name 41392_2025_2166_Tabbr_HTML.gif Kd ≈ 600 μM ClpB Inhibitor (NTD)
DBeQ graphic file with name 41392_2025_2166_Tabbs_HTML.gif aIC50 ≈ 5.0 μM ClpB Inhibitor (NTD)
Mizoribine graphic file with name 41392_2025_2166_Tabbt_HTML.gif / HSP60 inhibitor (NBD)
ETB graphic file with name 41392_2025_2166_Tabbu_HTML.gif cIC50 = 1.1 μM HSP60 inhibitor (Cys442 covalent site)
MC graphic file with name 41392_2025_2166_Tabbv_HTML.gif / HSP60 inhibitor (/)
O-carboranyl-phenoxyacetanilide graphic file with name 41392_2025_2166_Tabbw_HTML.gif cIC50 = 0.74 μM HSP60 inhibitor (NBD)
[Au(TPP)Cl] graphic file with name 41392_2025_2166_Tabbx_HTML.gif cIC50 = 1.1 μM HSP60 inhibitor (/)
KHS101 graphic file with name 41392_2025_2166_Tabby_HTML.gif cIC50 = 14 μM HSP60 inhibitor (/)
RP101 graphic file with name 41392_2025_2166_Tabbz_HTML.gif / HSP27 inhibitor (Phe29 and Phe33)
J2 graphic file with name 41392_2025_2166_Tabca_HTML.gif cIC50 = 99 μM HSP27 inhibitor (Cysteine-thiol group)
MK-933 graphic file with name 41392_2025_2166_Tabcb_HTML.gif / HSP27 inhibitor (NTD)

Kd target binding affinity, aIC50 ATPase inhibitor activity, bIC50 competitive binding activity, cIC50 inhibitory activity on molecular chaperone functions, “/” indicates no clear reports