TABLE 3.
Selectivity testing of BST-4 on a panel of 76 tyrosine kinases.
| Target | IC50 (μM) | Target | IC50 (μM) | Target | IC50 (μM) | Target | IC50 (μM) |
|---|---|---|---|---|---|---|---|
| ABL1 | >10 | EPHA8 | >10 | HCK | >10 | NTRK3 | >10 |
| ABL2 | >10 | EPHB1 | >10 | IGF1R | >10 | PDGFRA | >10 |
| ALK | >10 | EPHB2 | >10 | INSR | >10 | PDGFRB | >10 |
| AXL | >10 | EPHB3 | >10 | INSRR | >10 | PTK2 | >10 |
| BLK | >10 | EPHB4 | >10 | ITK | >10 | PTK2B | >10 |
| BMX | >10 | ERBB2 | >10 | JAK1 | >10 | PTK6 | >10 |
| BTK | >10 | ERBB4 | >10 | JAK2 | >10 | RET | >10 |
| CSF1R | >10 | FER | >10 | JAK3 | >10 | ROS1 | >10 |
| CSK | >10 | FES | >10 | KDR | >10 | SRC | >10 |
| DDR1 | >10 | FGFR1 | >10 | KIT | >10 | SRMS | >10 |
| DDR2 | >10 | FGFR2 | >10 | LCK | >10 | SYK | >10 |
| EGFR | >10 | FGFR3 | >10 | LTK | >10 | TEC | >10 |
| EPHA1 | >10 | FGFR4 | >10 | LYN | >10 | TEK | >10 |
| EPHA2 | >10 | FGR | >10 | MERTK | >10 | TNK2 | >10 |
| EPHA3 | >10 | FLT1 | >10 | MET | >10 | TXK | >10 |
| EPHA4 | >10 | FLT3 | >10 | MST1R | >10 | TYK2 | >10 |
| EPHA5 | >10 | FLT4 | >10 | MUSK | >10 | TYRO3 | >10 |
| EPHA6 | >10 | FRK | >10 | NTRK1 | >10 | YES1 | >10 |
| EPHA7 | >10 | FYN | >10 | NTRK2 | >10 | ZAP70 | >10 |