Objective: To remove the noise from the color-normalized image

Input: Histopathology Image (D)

Output: Pre-processed Image (P)

1: for each pixel (m,n) in D do

2: Compute normalization constant I’ using Eq. (6)

3: Initialize EANLM(m) as the filtered value for pixel (m,n)

4: for each patch (Gm ) in the template window around (m,n) do

5: Calculate weight w(m,n) based on Eq. (5)

6: Accumulate weighted intensity from patches (Gn ) in the search window around (m,n) using Eq. (7)

7: Assign EANLM(m) to P(m,n) using Eq. (8)

8: end for

9: Return P as the pre-processed image after noise reduction