Table 1. The nucleotide sequences around target sites in apple genome.

Target gene	Sequence
MD05G1312300	GAAAACATTTTAAGTGCTTTTAGAACCAAAAAATATTTTCTTTAAAAGTACTTTTAACCATTTTAAAAACACATCCAAACGAGCTCTTATTAGTTTCCATCTAGCATACGATAAGCTCCCTATCTTCTGTCAACCCTCGGCCTTCCCCCCCCCCAGTGTGCATTAATTAAGGAAGATTGACTTACTTTTAACCATTTTAAAAACACATTCAAACGAGCCCTTATTAGTTTCTACTAAGCATACGATAAGCTCCCTATCTTCTGTCAACCCTCGGCCTTCATTATACGTATGCACCACTGAAACTCCCACACCCCACCCCCCGGGCCCCCCGGTATGCATTAATTAAGGAATATTGGCTTCTTTGCTAGCACAATTTTGA
MD11G1251800	GCGAACCTTATGGAGAAAGCTCAAGCCGGAGAGTGGTTGGTCACCAATACAAAGAAAGTCAGACTAGATATCAGATCACGCCCCCAGGAAACTCTTCCTCCAAGCATTGTCAGATCAGATAAGGCCATGCATCTTGTGATCTGCTCTCTACATGCTCTCTCTCTTCTGTCATCCGTGGCTTTGTTTCTAGGCCATTACATATGTGAGCTTCTAAAGCTATTCTGGTGTATGGTTATGTAGTTTCGACTTGTGTTAAAACTAATCCTTAACACTATTCTGGATGTTTCAATAAGACAATTGGGAATG

The red characters indicate the 20 bp target sequences of SpCas9. The italicized characters indicate PAM sequences. The underlined characters indicate the predicted miR156 target sequences.