Table 1.
Population-level changes in visual response properties for ON BC and RGC optogenetic targeting
| Visual response property | ReaChR in RGCs compared with ON BC (population-level) |
|
|---|---|---|
| Retina | dLGN | |
| Photosensitivity | similar in both | – |
| Maximum firing rate | lower in RGC | similar in both |
| Response reproducibility | lower in RGC | lower in RGC |
| Sensitivity normalization | present and similar in both | – |
| Response onset latency | shorter in RGC | shorter in RGC |
| Response polarity | more ON-biased in RGC (missing OFF/biphasic units) | more ON-biased in RGC |
| Response transience | more sustained in RGC (missing highly transient units) | similar in both |
| Contrast sensitivity | less sensitive in RGC (missing units with high contrast sensitivity) | less sensitive in RGC |
| Temporal frequency tuning | more stereotyped in RGC (missing units with low- or high-pass tuning) | more stereotyped and biased to higher frequencies in RGC |
| Diversity of visual responses | reduced in RGC | similar in both |
| Visual code compared with WT | less WT-like in RGC | less WT-like in RGC |