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. 2025 Mar 6;12(3):ENEURO.0251-24.2025. doi: 10.1523/ENEURO.0251-24.2025

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Copyright © 2025 Guillaume et al.

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Figure 2. — LY IP injection reduces evoked PSP amplitude in direct and indirect MSNs in vivo. A, Representative trace of whole-cell recordings in DLS and of contralateral S2 LFP following an electrical stimulation in ipsilateral S2 (red line). B, Average (thick line) and variance (shading) MSN PSPs in downstate before and after injection of CCK2R antagonist LY (orange line). C, Effect of LY injection on MSN PSPs amplitude in cells from both direct (D1) and indirect (D2) MSNs (n = 12). D, On normalized PSP amplitude in direct (D1, n = 8) and indirect (D2) MSNs (n = 4). Significant diminution of the PSP slope in both direct (D1) or indirect (D2, n = 4) MSNs and on E, PSP slope in combined D1 and D2 MSNs (n = 12). Dots and squares are individual cells before (black) and after (orange) LY application; **p < 0.01; ***p < 0.001.