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. 2025 Mar 6;12(3):ENEURO.0251-24.2025. doi: 10.1523/ENEURO.0251-24.2025

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Copyright © 2025 Guillaume et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 3. — CCK2R antagonist LY application modulates MSN membrane properties ex vivo. A, Left, Schematic representation of the horizontal corticostriatal rat brain slice preparation with the recording electrode in the striatum (Str). Right, Schematic representation of the experience timeline. B, Effect of LY application on MSN spike and rheobase (n = 6). B, Example traces of MSN responses to current injections of increasing amplitude before and after LY application. C,D, Effect of CCK2R antagonist LY application on MSN spike threshold and rheobase (n = 5). Dots and squares are individual cells before (black) and after LY (orange). E,F, Effect of CCK1R antagonist Lorg application on MSNs spike threshold and rheobase (n = 14). Dots and squares are individual cells before (black) and after Lorg (pink) application; *p < 0.05.