Figure 5.

CCK2R blocker LY switches long-term STDP from potentiation to depression. A, STDP protocol, with post–pre pairing repeated 100 times at 1 Hz (top), and evoked EPSCs from a representative MSN during baseline and long-term conditions under control, LY, or Lorg application. B,C, Normalized EPSC amplitude (top and right) and input resistance (bottom) to preplasticity induction in control and LY conditions (black control n = 10; orange LY n = 9). D, Normalized 1/CV² of control condition and LY condition. E,F, Normalized EPSC amplitude (top and right) and input resistance (bottom) to preplasticity induction in control and Lorg conditions (black control n = 10; pink Lorg n = 9). Dots/squares are mean, and error bars are ±SEM; ****p < 0.0001.