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. 2025 Feb 10;17(2):e78802. doi: 10.7759/cureus.78802

Table 2. Differentiation of peripheral vertigo, central vertigo, and CBZ toxicity.

This table compares key features of peripheral vertigo, central vertigo, and CBZ toxicity. It highlights differences in symptoms, triggers, and physical findings, helping clinicians distinguish CBZ toxicity from other causes of dizziness.

CT: computed tomography; MRI: magnetic resonance imaging; CBZ: carbamazepine

Types of Vertigo Peripheral Vertigo Central Vertigo Carbamazepine Toxicity (Drug-Induced Vertigo)
Associated Symptoms Tinnitus, hearing loss, ear fullness, nausea Neurological symptoms (paralysis, numbness, speech impairment, diplopia), nausea, headache Fatigue, drowsiness, nausea, confusion, ataxia, decreased consciousness, arrhythmia, syncope
Onset Acute, episodic Sudden or gradual, persistent Acute, persistent
Triggers Positional changes (head or body) No specific triggers Dose increase, addition of other medications
Physical Findings Horizontal nystagmus, direction-fixed nystagmus, mild balance disturbance, inner ear impairment Vertical or direction-changing nystagmus, skew deviation, diplopia, dysarthria, dysphagia, dysphonia, dysmetria, dysdiadochokinesis Vertical nystagmus, myoclonus, delayed reactions, impaired consciousness, seizures, diplopia, dysarthria, dysphagia, various other neurological findings
Additional Tests Hearing tests, caloric testing, positional nystagmus tests (vestibular function tests) Brain MRI, CT, neurological examinations Blood carbamazepine level testing; blood tests for liver/kidney function, and electrolyte