KRAS	Kirsten rat sarcoma viral oncogene homolog
TME	Tumor microenvironment
NRAS	Neuroblastoma rat sarcoma virus
HRAS	Harvey rat sarcoma virus
MAPK	Mitogen-activated protein kinase
PI3K	Phosphoinositide 3-kinase
RAL-GEF	Ral guanine nucleotide exchange factors
NSCLC	Non-small cell lung cancer
PDAC	Pancreatic ductal adenocarcinoma
CRC	Colorectal cancer
LAC	Lung adenocarcinoma
EGFR	Estimated glomerular filtration rate
GRB2	Growth factor receptor-bound protein 2
GEF	Guanine nucleotide exchange factor
MAP/ERK	Mitogen-activated protein kinases/extracellular signal-regulated kinases
NMDAR	N-methyl-D-aspartate receptor
Camp	Cyclic adenosine monophosphate
ShP2	Src homology region 2 (SH2)-containing protein tyrosine phosphatase 2
PDK1	3-Phosphoinositide-dependent kinase 1
MDSCs	Myeloid-derived suppressor cells
TMB	Tumor mutational burden
TILs	Tumor-infiltrating lymphocytes
PD-1/PD-L1	Programmed cell death Ligand 1