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. 2025 Feb 22;17(5):752. doi: 10.3390/cancers17050752
ACSL3 Acyl-coenzyme A (CoA) synthetase long-chain family member 3;
AKT Protein kinase B;
AMPK 5′ AMP-activated protein kinase;
6-AN 6-anicotinamide;
Anlo Anlotinib;
APC Adenomatous polyposis coli;
ASK1 Apoptosis signal-regulating kinase 1;
ATPP-DTPA 5-(4-amino-phenyl)-10,15,20-triphenylporphyrin-diethylene-triaminopentaacetic acid;
ATF4 Activating transcription factor 4;
BER Base excision repair;
BMP Bone morphogenetic protein;
BRAF B-Raf proto-oncogene;
CAFs Cancer-associated fibroblasts;
CAT Catalase;
CDDP Cisplatin;
CDK Cyclin-dependent kinase;
CIN Chromosomal instability;
CIOSS CRC-integrated OS score;
CM-H2DCFDA 5-(and 6)-chloromethyl-2′,7′-dichlorohydrofluorescein diacetate;
COX-2 Cyclooxygenase-2;
CPT-11 Irinotecan;
CRC Colorectal cancer;
CTLA-4 Cytotoxic T lymphocyte-associated protein 4;
CtBP1 C-terminal binding protein-1;
CXCL2 C-X-C motif chemokine ligand 2;
Cyt-c Cytochrome-c;
DCF 2′,7′-dichlorofluorescein;
DHA Dihydroartemisinin;
DHE Dihydroethidium;
d-ROMs Reactive oxygen metabolite derivatives;
Dvl Dishevelled protein 1;
DTNB 5,5′-dithio-bis(2-nitrobenzoic acid);
EGFR Epidermal growth factor receptor;
ELISA Enzyme-linked immunosorbent assay;
EMT Epithelial-to-mesenchymal transition;
ER Endoplasmic reticulum;
ERK Extracellular signal-regulated kinase;
FGFR Fibroblast growth factor receptor;
FLIM Fluorescence lifetime imaging microscopy;
5-FU 5-fluorouracil;
G6PD Glucose-6-phosphatedehydrogenase;
GGT2 Gamma-glutamyltransferase 2;
GOT1 Glutamic-oxaloacetic transaminase 1;
GPXs Glutathione peroxidases
GSH Glutathione;
GSS Glutathione synthase;
GSSG Oxidized glutathione
GSTs Glutathione S-transferases;
Gyp Gypenosides;
H2DCF 2′,7′-dichlorodihydrofluorescein;
H2DCFDA 2′,7′-dichlorodihydrofluorescein diacetate;
H2O2 Hydrogen peroxide;
HER Human epidermal growth factor receptor;
HIF-1α Hypoxia-inducible factor 1α;
HPLC High-pressure liquid chromatography;
HY-PDT Photodynamic therapy mediated by hypericin;
IBD Inflammatory bowel diseases;
ICAM-1 Intercellular adhesion molecule 1;
IFN Interferon;
IFN-α Interferon-alpha;
IKK Inhibitor κB kinase;
ISC Intestinal stem cell;
JAK Janus kinase;
JNK c-Jun N-terminal kinase;
Keap1 Kelch-like ECH-associated protein 1;
KRAS KRAS proto-oncogene, GTPase;
LncRNAs Long noncoding RNAs;
L-OHP Oxaliplatin;
mAbs Monoclonal antibodies;
MAPK Mitogen-activated protein kinase;
MAP3K Mitogen-activated protein kinase kinase kinase;
MDA Malondialdehyde;
MDR Multidrug resistance;
MEK Mitogen-activated protein kinase kinase-MAPKK;
MET Metformin;
MLK3, MAP3K11 Mixed lineage kinase 3;
MMR Mismatch repair;
MPO Myeloperoxidase;
MSI Microsatellite instability;
MSI-H Microsatellite instability-high;
mTOR Mammalian target of rapamycin;
MUTYH MutY homolog Escherichia coli, homolog of MYH, hMYH;
MVs Membrane vesicles;
NaB Sodium butyrate;
NAC N-acety1 cysteine;
NADPH Nicotinamide adenine dinucleotide phosphate;
NPs Nanoparticles;
NER Nucleotide excision repair;
NF-κB Nuclear factor kappa B;
NIK NF-κB inducing kinase;
NOTCH Notch receptor;
NOX NADPH oxidase;
NRAS NRAS proto-oncogene, GTPase;
NRF2 Nuclear factor-erythroid 2 p45-related factor 2;
NRX Nucleoredoxin;
NSAIDs Nonsteroidal anti-inflammatory drug;
O2•− Superoxide anion;
OGG1 8-oxoguanine DNA glycosylase 1;
•OH Hydroxyl radical;
8-OHdG 8-hydroxy-2′-deoxyguanosine;
8-oxoG 8-oxoguanine;
8-oxodG 8-oxo-7, 8-dihydro-2′-deoxyguanosine;
oxLDL Oxidized low-density lipoprotein;
OS Oxidative stress
P3C-Asp Dextran–aspirin nanomedicine;
PD-1 Programmed cell death 1;
PDGF-R Platelet-derived growth factor receptors;
PDL1 Programmed death ligand 1;
PDT Photodynamic therapy;
PFL Positive feedback loop;
P-gp P-glycoprotein;
PI3K Phosphatidyl inositol 3-OH kinase;
PKB Protein kinase B;
PL Piperlongumine;
PMN Polymorphonuclear;
PPP Pentose phosphate pathway;
PRX Peroxiredoxin;
PTEN Phosphatase and tensin homolog;
PTKs Protein tyrosine kinases;
PTP Protein tyrosine phosphatase;
PUFAs Polyunsaturated fatty acids;
PL Piperlongumine;
qPCR Quantitative real-time polymerase chain reaction;
RAC1 Rac family small GTPase 1;
ROS Reactive oxygen species;
RTKs Receptor tyrosine kinases;
SA Salicylic acid;
SalB Salvianolic acid B;
SCD1 Stearoyl-CoA desaturase-1;
SLC7A11 Solute carrier family 7 member 11;
SMAD4 SMAD family member 4/mothers against decapentaplegic homolog 4;
SOD Superoxide dismutase;
STAT Signal transducer of activators of transcription;
TALDO1 Transaldolase 1;
TAMs Tumor-associated macrophages;
TANs Tumor-associated neutrophils;
TBA Modified 2-thiobarbituric acid;
TBARS Thiobarbituric acid reactive;
TCA Tricarboxylic acid cycle;
TCF-4 T-cell factor-4;
TCRs T-cell receptors;
TIGAR TP53-induced glycolysis regulatory phosphatase;
TGF-β Transforming growth factor-β;
TKI Tyrosine kinase inhibitor;
TME Tissue microenvironment;
TNFR Tumor necrosis factor receptor;
TRAF3 Tumor necrosis factor receptor-associated factor 3;
Trx/TrxR Thioredoxin/thioredoxin reductase;
VCAM1 Vascular cell adhesion molecule 1;
VEGF Vascular endothelial growth factor;
VEGFR Vascular endothelial growth factor receptor;
Wnt Wingless/It;
Wnt-PCP Wnt-planar cell polarity;
xCT xc− transporter;
X-PDT X-ray-induced photodynamic therapy.