Table 4.

Comparison of sorted class list against GENERATOR clustering with itraconanzole dataset. The table shows the sorted list of over-represented functional classes for itraconanzole dataset. Only the 25 best scoring classes are shown to limit the size. Columns are same as in table 2. Notice that most of the functional classes are associated with amino acid biosynthesis. Detailed results are shown in table 8 [see Additional file 8].

Rank	Class	O.log(p)	In cluster
1	amino acid biosynthesis	19.07	I
2	amine biosynthesis	18.08	I
3	carboxylic acid metabolism	14.77	I
4	organic acid metabolism	14.77	I
5	amino acid metabolism	14.70	I
6	amino acid and derivative metabolism	13.75	I
7	amine metabolism	13.02	I
8	arginine biosynthesis	11.28	I
9	steroid metabolism	8.89	II
10	nitrogen metabolism	8.79	not reported
11	urea cycle intermediate metabolism	8.66	not reported
12	arginine metabolism	8.66	not reported
13	Biosynthesis	8.52	I, II
14	transaminase activity	8.32	not reported
15	transferase activity, transferring nitrogenous groups	8.32	not reported
16	glutamine family amino acid biosynthesis	8.16	not reported
17	sterol metabolism	8.02	II
18	glutamine family amino acid metabolism	7.99	I
19	sterol biosynthesis	7.77	II
20	steroid biosynthesis	7.69	II
21	ergosterol biosynthesis	6.22	II
22	ergosterol metabolism	6.22	II
23	aromatic compound metabolism	5.85	not reported
24	branched chain family amino acid metabolism	5.61	not reported
25	cyclohydrolase activity	5.50	not reported