FIG. 6.

Papillary tissue osmolality, urea, and chloride concentrations. Papillae were dissected from mice dehydrated for 36 h and homogenized in water. Homogenate concentrations were measured to determine total osmolality, urea, and chloride concentrations within the tissue samples, which were then divided by the wet tissue weight of papillae. Fed a low protein diet, UT-A2^−/− mice had reduced papillary osmolality and a reduced medullary urea concentration, compared to wild-type mice. P < 0.05, n = 5.