FIG. 2.
Trypanosome SNAP26 resembles an internally deleted metazoan SNAP43. (A) The sequence alignment shows the similarity of the amino-terminal half of T. brucei (Tb) SNAP26 to human (Homo sapiens [Hs]) (NP_003073) and Drosophila (Dm) (NP_650499) SNAP43. The alignment was obtained using the CLUSTALW program and refined manually. Dark shading indicates identical or conserved residues in all three proteins. Medium shading highlights similarity between two proteins. The underlined region shows the T. brucei SNAP26 sequence that corresponds to Edman-derived data from the purified L. seymouri p36 subunit of tSNAPc (our unpublished data). (B) Schematic of proteins. Dashed lines indicate regions of similarity among the proteins. Percent identities and similarities are shown. The central region of the metazoan proteins (indicated by a gray box) is absent from the trypanosome protein.