FIG.3.

Hierarchical clustering of WW domains with precipitated proteins. The GST-WW domains (abscissa) and precipitated proteins (ordinate) were hierarchically clustered as outlined in Materials and Methods. The tree at the top indicates the relatedness of the WW domains with respect to precipitated proteins. This clustering distinguishes three groups of WW domains: group A (AIP4 WW2, NEDD4-1 WW2, and WWOX WW1) in yellow, group B (FBP11 WW1 and WW2, FBP21 WW2, FE65 WW, CA150 WW2, and Gas7 WW) in red, and group C (Pin1 WW) in green. The color of the precipitated protein indicates cellular function and is shown to the right.