TABLE 2.
Coagulation and Transfusion Measures by Achieving Hemostasis
| Achieved Hemostasis | ||||
|---|---|---|---|---|
| Measure | All (N = 1,047) | Yes (n = 898) | No (n = 149) | p |
| Coagulation parameter | ||||
| Within 4 h of arrival | ||||
| Prothrombin time, s | 15.1 [13.6–16.6] | 15.1 [13.6–16.6] | 14.6 [12.7–16.5] | 0.19 |
| International normalized ratio | 1.23 [1.15–1.40] | 1.24 [1.15–1.40] | 1.20 [1.10–1.40] | 0.17 |
| Rapid thromboelastography | ||||
| Kinetic time, m | 1.90 [1.50–2.70] | 1.90 [1.50–2.60] | 1.95 [1.70–3.30] | 0.05 |
| >2.5 | 200 (27.7) | 176 (26.6) | 24 (40.0) | 0.03 |
| α Angle, ° | 69.3 [63.9–73.0] | 69.4 [64.1–73.2] | 68.4 [57.0–72.4] | 0.04 |
| <60 | 113 (15.5) | 95 (14.3) | 18 (28.6) | <0.01 |
| Maximum amplitude, mm | 57.0 [51.6–61.6] | 57.0 [52.1–61.6] | 54.6 [42.6–60.7] | <0.01 |
| <55 | 289 (39.5) | 256 (38.3) | 33 (52.4) | 0.03 |
| Clot lysis at 30 m, % | 0.00 [0.00–0.40] | 0.00 [0.00–0.30] | 0.00 [0.00–0.90] | 0.01 |
| >3 | 16 (2.4) | 12 (1.9) | 4 (6.6) | 0.02 |
| Activated clotting time, s | 113 [105–128] | 113 [105–128] | 113 [105–128] | 0.67 |
| >128 | 117 (17.9) | 107 (18.0) | 10 (17.5) | 0.93 |
| Within 24 h of arrival | ||||
| Prothrombin time, s | 15.7 [14.3–17.0] | 15.8 [14.4–17.1] | 14.7 [13.8–16.0] | 0.02 |
| International normalized ratio | 1.30 [1.20–1.46] | 1.30 [1.20–1.46] | 1.23 [1.16–1.31] | 0.04 |
| Rapid thromboelastography | ||||
| Kinetic time, m | 1.30 [1.10–1.70] | 1.30 [1.10–1.70] | 1.20 [1.00–1.70] | 0.53 |
| >2.5 | 40 (6.1) | 36 (5.9) | 4 (9.5) | 0.34 |
| α Angle, ° | 74.4 [71.2–76.8] | 74.4 [71.3–76.8] | 74.4 [70.8–77.1] | 0.98 |
| <60 | 14 (2.1) | 11 (1.8) | 3 (7.1) | 0.02 |
| Maximum amplitude, mm | 63.9 [59.7–68.0] | 63.9 [59.6–67.9] | 64.1 [60.2–68.5] | 0.63 |
| <55 | 57 (8.6) | 53 (8.6) | 4 (9.5) | 0.83 |
| Clot lysis at 30 m, % | 0.20 [0.00–1.00] | 0.20 [0.00–0.90] | 0.65 [0.00–1.90] | <0.01 |
| >3 | 19 (3.0) | 16 (2.7) | 3 (7.1) | 0.10 |
| Activated clotting time, s | 113 [105–128] | 113 [105–128] | 105 [97.0–128] | 0.16 |
| >128 | 103 (16.7) | 97 (16.8) | 6 (15.4) | 0.82 |
| Transfusion requirement | ||||
| Within 4 h of arrival | ||||
| Whole, U | 1.00 [0.00–2.00] | 1.00 [0.00–2.00] | 0.00 [0.00–2.00] | 0.13 |
| Red cells, U | 4.00 [2.00–10.0] | 4.00 [1.00–9.00] | 12.0 [2.00–30.0] | <0.001 |
| Plasma, U | 3.00 [0.00–8.50] | 3.00 [0.00–8.00] | 10.0 [0.00–22.0] | <0.001 |
| Platelets, U | 0.00 [0.00–1.00] | 0.00 [0.00–1.00] | 1.00 [0.00–3.00] | <0.001 |
| Total, U | 9.00 [4.00–22.0] | 9.00 [4.00–19.0] | 26.5 [2.00–56.0] | <0.001 |
| Total, mL | 3,180 [1,330–6,880] | 2,990 [1,330–5,815] | 8,925 [990–18 k] | <0.001 |
| Within 24 h of arrival | ||||
| Whole, U | 1.00 [0.00–2.00] | 1.00 [0.00–2.00] | 0.00 [0.00–2.00] | 0.17 |
| Red cells, U | 5.00 [2.00–12.0] | 4.00 [2.00–10.0] | 12.0 [2.00–39.0] | <0.001 |
| Plasma, U | 4.00 [0.00–10.0] | 3.00 [0.00–9.00] | 10.0 [0.00–25.0] | <0.001 |
| Platelets, U | 1.00 [0.00–2.00] | 0.00 [0.00–2.00] | 1.00 [0.00–4.00] | <0.001 |
| Total, U | 11.0 [4.00–25.0] | 10.0 [4.00–22.0] | 26.5 [2.00–67.0] | <0.001 |
| Total, mL | 3,605 [1,500–8,090] | 3,225 [1,540–7,075] | 8,925 [990–21 k] | <0.001 |
Data are presented as n (%), mean ± SD, or median [Q1–Q3].