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. 2005 Aug;25(16):7158–7169. doi: 10.1128/MCB.25.16.7158-7169.2005

FIG. 2.

FIG. 2.

DSBs and homologous recombination induced by camptothecin depend on replication. (A) Pulsed-field gel electrophoresis showing DNA fragmentation following a 6-hour treatment with camptothecin (200 nM) and/or aphidicolin (3 μM). (B) Homologous recombination measured as the frequency of reversion to HAsT-resistant colonies in S8SN.11 cells following a 6-hour treatment with camptothecin (200 nM) and/or aphidicolin (3 μM). The average (column) and standard deviation (error bars) of three experiments are depicted.