FIG. 1.

(A) Sites of mutations in Su(Tpl) alleles. Mutational lesions are indicated in red above the wild-type amino acid sequence of dELL at the site of the mutation. For frameshift alleles, the resulting out-of-frame peptide is also shown. (B) Effects of Su(Tpl) alleles on sev-Ras1^v12 (top) and GMR-yan^ACT (bottom). The dELL polypeptide is represented by a horizontal bar. Filled intervals represent conserved homology to the N-terminal ELL elongation domain and the C-terminal ZO-1 occludin binding domain. Alleles with an enhancer effect are shown in red, alleles with a suppressor effect are shown in blue, and alleles with no apparent effect are shown in black.