FIG. 7.

CSB-deficient cells are sensitive to PARP inhibitors. (A) Clonogenic survival of CS1AN/CSBwt (WT) and CS1AN/vector (VECTOR) cells after treatment with the indicated amounts of the PARP inhibitor 3-AB. Solid triangles indicate survival of WT cells. Solid circles indicate survival of vector cells. Data represent the means and standard deviations of four triplicate experiments. (B) MTT survival of CS1AN/CSBwt (WT) cells, indicated by solid triangles, and CS1AN/vector (VECTOR) cells, indicated by solid circles, after treatment with the PARP inhibitor DPQ. Data represent the means and standard deviations of five triplicate experiments.