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Activity of CSBa
| Characteristic | CSB activity
|
|||||
|---|---|---|---|---|---|---|
| CSBwt | Vector | CSBE8646Q | CSBT912-913V | CSBQ942E | CSBR946A | |
| Protein | ||||||
| ATPase activity | +++ | ND | ÷ | + | + | ND |
| ATP binding | +++ | ND | +++ | +++ | +++ | ND |
| DNA binding | +++ | ND | +++ | ++ | ++ | ND |
| Cellular | ||||||
| UV survival | +++ | ÷ | ÷ | ÷ | ÷ | ÷ |
| γ survival | +++ | ÷ | ND | ++ | + | + |
| 8-oxoG incision | +++ | ÷ | +++ | ++ | + | + |
| 3-AB survival | +++ | ÷ | ÷ | + | + | ÷ |
+++, same activity as CSBwt protein; ++, lower but still significant activity; +, deficient but residual activity; ÷, deficient; ND, not determined.
