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Lower level of H-ferritin in Fermut cells results in low total cellular iron and high basal LIP levels compared with levels in wild-type cells (Wt). (a) Total cellular iron in wild-type, Fermut, and reconstituted lines was measured. H-ferritin deficiency results in reduced total cellular iron. (b) LIP levels in wild-type, Fermut, and reconstituted lines were measured. The results indicate that H-ferritin mutation leads to an increase in the steady level of LIP.
